Modulators of Candida Hyphal Morphogenesis and Uses Thereof
AssigneeAgency for Science, Technology and Research
InventorsYue Wang, Xiao-Li Xu, Raymond Teck Ho Lee
Life of this patent
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Abstract
The invention relates to modulation of fungal morphology between yeast-to-hyphal growth transition by controlling muramyl-L-alanine concentration and uses thereof.
Claims33
A method of modulating morphogenesis of a fungus by controlling the concentration of muramyl-L-alanine in the fungal environment.
A method for treating a patient to at least reduce Candida hyphal growth, which comprises the step of contacting the infection with an antagonist to muramyl-L-alanine and/or compounds that include muramyl-L-alanine in the core structure.
A method of modulating morphogenesis of a fungus in a patient comprising the steps of:
- a. preparing a composition comprising an adjuvant and a compound with a muramyl-L-alanine in the core structure;
- and
- b. administering the composition to the patient.
A composition comprising a therapeutically effective amount of a modulator of muramyl-L-alanine concentration.
(canceled)
(canceled)
A method of determining the extent of Candida hyphal growth in a sample comprising the step of measuring the amount of muramyl-L-alanine and/or compounds that include muramyl-L-alanine in their core structure in body fluids sampled from a Candida infection.
A method for screening for agonists and antagonists of Candida hyphal growth comprising the steps of:
- a. contacting (i) muramyl-L-alanine and/or compounds that include muramyl-L-alanine in their core structure and (ii) the LRR domain of CaCdc35p from a Candida species with a sample compound;
- and
- b. detecting whether the sample compound exhibits agonistic or antagonistic activity towards the interaction.
(canceled)
Dependencies are inferred from the claim text.