Growth factor homolog zvegf4
AssigneeZymoGenetics, Inc.
InventorsTeresa Gilbert, Charles E. Hart, Paul O. Sheppard
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Abstract
Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 70% identical to residues 52-179 of SEQ ID NO:2 or residues 258-370 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
Claims16
An isolated polynucleotide of up to approximately 4.4 kb in length, wherein said polynucleotide encodes a polypeptide comprising residues 52-370 of SEQ ID NO:2.
An expression vector comprising the following operably linked elements:
- a transcription promoter;
- a DNA segment encoding a polypeptide comprising residues 52-370 of SEQ ID NO:2;
- and
- a transcription terminator.
Dependencies are inferred from the claim text.