Novel identified oncogene with kinase-domain (nok)
AssigneeTsinghua University
InventorsLi Liu, Xinyuan Fu, Zhijie Chang, Shuping Zhang
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Abstract
A newly identified oncogene with kinase-domain (NOK) and its encoded polypeptide, and vectors, fusions, host cells and transgenic animals comprising the said nucleotide sequence. Furthermore, the present invention also describes the methods for diagnosing diseases including tumor and the methods for screening agents capable of inhibiting the occurrence and/or metastasis of tumor.
Claims38
An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
- 1) the nucleotide sequence of SEQ ID No:
- 1;
- 2) a nucleotide sequence encoding the amino acid sequence of SEQ ID No:
- 2;
- and
- 3) a nucleotide sequence having at least 90% sequence identity with that of 1) or 2),
- Wherein the isolated polynucleotide encodes a product of Novel Oncogene with Kinase-domain (NOK).
An isolated polynucleotide encoding a chimeric molecule fused between NOK and at least one heterogeneous polypeptide.
An isolated polypeptide comprising the amino acid sequence of SEQ ID No:
- 2, or a biologically active fragment or derivative thereof.
A fusion polypeptide, which is a chimeric molecule fused between NOK and at least one heterogeneous polypeptide.
A polypeptide epitope, wherein the polypeptide epitope has a sequence as shown in SEQ ID No:
- 10, corresponding to amino acid residues 360th to 380th of the amino acid sequence of NOK.
A mutant of EPOR/NOK comprising a single mutation at tyrosine residue 327 or 356 of NOK in the chimeric receptor EPOR/NOK.
Dependencies are inferred from the claim text.