System for iontophoretic transdermal delivery of polymeric agents and methods of use thereof
OwnerShmuel Bukshpan, Gleb Zilbersteininventors
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Abstract
A system for iontophoretic transdermal delivery of a non-peptidic polymeric cosmetic or therapeutic agent or of a polypeptide useful for delivery of high molecular weight cosmetic or therapeutic agents. Particularly, the present invention relates to a system that includes an iontophoresis device and a pharmaceutical composition of a non-peptidic polymeric cosmetic or therapeutic agent together with a peptide, polypeptide or protein and a pharmaceutically acceptable carrier having a pH below or above the isoelectric pH of the peptide, polypeptide or protein.
Claims24
-27. (canceled)
A system for iontophoretic transdermal delivery of a non-peptidic cosmetic or therapeutic agent comprising an iontophoresis device comprising at least one agent reservoir adapted for holding a cosmetic or pharmaceutical composition, wherein the cosmetic or pharmaceutical composition comprising as active ingredients a non-peptidic polymeric cosmetic or therapeutic agent and a peptide, polypeptide or protein, and a pharmaceutically acceptable carrier, wherein the pharmaceutically acceptable carrier has a pH of at least one pH unit below or above the isoelectric pH of the peptide, polypeptide or protein, thereby increasing the positive or negative charge of the peptide, polypeptide or protein.
A system for iontophoretic transdermal delivery of a polypeptide comprising at least one hundred amino acid residues, the system comprises an iontophoresis device comprising at least one agent reservoir adapted for holding a cosmetic or pharmaceutical composition, wherein the cosmetic or pharmaceutical composition comprises as an active ingredient a polypeptide comprising at least one hundred amino acid residues, and a pharmaceutically acceptable carrier, wherein the pharmaceutically acceptable carrier has a pH of at least one pH unit below or above the isoelectric pH of the polypeptide, thereby increasing the positive or negative charge of said polypeptide.
A method for iontophoretic transdermal delivery of a non-peptidic polymeric cosmetic or therapeutic agent, which comprises:
- removing the stratum corneum from a predetermined site on the skin of a subject;
- providing a system for iontophoretic transdermal delivery comprising an iontophoresis device comprising at least one agent reservoir adapted for holding a pharmaceutical or cosmetic composition, wherein the pharmaceutical or cosmetic composition comprises as active ingredients a non-peptidic polymeric cosmetic or therapeutic agent and a peptide, polypeptide or protein, and a pharmaceutically acceptable carrier, wherein the pharmaceutically acceptable carrier has a pH of at least one pH unit below or above the isoelectric pH of the peptide, polypeptide or protein, thereby increasing the positive or negative charge of said peptide, polypeptide or protein;
- placing the at least one agent reservoir in contact with the site on the skin of the subject;
- and
- delivering the non-peptidic polymeric cosmetic or therapeutic agent and the peptide, polypeptide or protein to the subject by iontophoresis.
A method for iontophoretic transdermal delivery of a polypeptide comprising at least one hundred amino acid residues, which comprises:
- removing the stratum corneum from a predetermined site on the skin of a subject;
- providing a system for iontophoretic transdermal delivery comprising an iontophoresis device comprising at least one agent reservoir adapted for holding a cosmetic or pharmaceutical composition, wherein the cosmetic or pharmaceutical composition comprises as an active ingredient a polypeptide comprising at least one hundred amino acid residues, and a pharmaceutically acceptable carrier, wherein the pharmaceutically acceptable carrier has a pH of at least one pH unit below or above the isoelectric pH of the polypeptide, thereby increasing the positive or negative charge of said polypeptide;
- placing the agent reservoir in contact with the site on the skin of the subject;
- and
- a) delivering said polypeptide to the subject by iontophoresis.
Dependencies are inferred from the claim text.