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AssigneeZymoGenetics, Inc.
InventorsCindy A. Sprecher, Julla E. Novak, James W. West, Scott R. Presnell, Richard D. Holly, Andrew J. Nelson
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Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for soluble zalpha11 receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block zalpha11 Ligand activity in vitro and in vivo, and may be used in conjunction with zalpha11 Ligand and other cytokines to selectively stimulate the immune system. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
An isolated heterodimeric receptor complex comprising receptor subunits, wherein the first receptor subunit comprises a receptor polypeptide comprising a sequence of amino acid residues as shown in SEQ ID NO:6, and wherein the second receptor subunit comprises a IL-2Rγ receptor polypeptide (SEQ ID NO:4).
An isolated heterodimeric receptor complex comprising two receptor subunits, wherein the first receptor subunit comprises a receptor polypeptide comprising a sequence of amino acid residues as shown in SEQ ID NO:2 from amino acid number 20 (Cys), to amino acid number 538 (Ser), and wherein the second receptor subunit comprises an IL-2Rγ receptor polypeptide.
An isolated multimeric receptor complex comprising receptor subunits, wherein at least one of receptor subunits comprises a receptor polypeptide comprising a sequence of amino acid residues as shown in SEQ ID NO:6, and wherein at least one other of the receptor subunits comprises a receptor polypeptide comprising IL-2Rγ receptor polypeptide (SEQ ID NO:4).
An isolated multimeric receptor complex comprising receptor subunits, wherein at least one of receptor subunits comprises a receptor polypeptide comprising a sequence of amino acid residues as shown in SEQ ID NO:2 from amino acid number 20 (Cys), to amino acid number 538 (Ser), and wherein at least one other of the receptor subunits comprises a receptor polypeptide comprises an IL-2Rγ receptor polypeptide.
Dependencies are inferred from the claim text.