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US 2009/0221602 A1Published application
Processes for preparing substituted pyrimidines
AssigneeVertex Pharmaceuticals Incorporated
InventorsJean-Damien Charrier, Francesca Mazzei, David Kay, Andrew Miller
Life of this patent
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Abstract
The present invention provides a facile process for the preparation of tri- and tetra-substituted pyrimidines. The process is useful for preparing inhibitors of protein kinases, especially Aurora kinase. These inhibitors are useful for treating or lessening the severity of Aurora-mediated diseases or conditions.
Claims23
A compound of formula V:
- or a pharmaceutically acceptable derivative or salt thereof, wherein:
- R5 is selected from hydrogen or C1-4 aliphatic;
- R6 is selected from C1-3 aliphatic;
- and
- R7 is selected from C1-4 aliphatic.
2 more elements
A compound selected from the following Table 1 compounds:
- TABLE 1
- No. V-
- Structure
- 1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 9
- 10
- 11
- 12
- 13
- 14
- 15
- 16
- 17
- 18
- 19
- 20
20 more elements
A compound selected from the following Table 3 compounds:
- TABLE 3
- V-1 i
- V-1 ii
- V-1 iii
- V-1 iv
- V-1 v
- V-1 vi
- V-1 vii
- V-1 viii
- V-1 ix
- V-1 x
- V-1 xi
- V-20 i
10 more elements
Dependencies are inferred from the claim text.