Use of Factor VII Polypeptides for Neuroprotection
AssigneesNovo Nordisk A/S, The Trustees of the University of Pennsylvania
InventorsRasmus Rojkjaer, Douglas Smith
Life of this patent
Estimating the term…
Abstract
New methods and compositions for providing neuroprotection in gyrencephalic mammals comprising a neuroprotective dose of Factor Vila or a neuroprotective Factor Vila equivalent are provided.
Claims21
A method for providing neuroprotection in a gyrencephalic mammal suffering from or at substantial risk of developing a neuropathological condition not primarily induced by apoptosis comprising administering to the mammal a neuroprotective-effective dose of Factor VIa or a neuroprotective Factor VIa equivalent and assessing the neurological state of the mammal.
A method for providing neuroprotection in a mammal that is suffering from or is at substantial risk of developing a neuropathological condition that manifests as a seizure disorder or neuropsychiatric disorder comprising administering to the mammal a neuroprotective-effective dose of Factor VIa or a neuroprotective Factor VIa equivalent.
A method for providing neuroprotection in a mammal that is suffering from or is at substantial risk of developing a neuropathological condition that manifests as a blinding eye disease, comprising administering to the mammal a neuroprotective-effective dose of Factor VIa or a neuroprotective Factor VIa equivalent.
A method of providing neuroprotection in a mammal suffering from or being at substantial risk of developing a white matter disease-associated or injury-associated neuropathological condition comprising administering to the mammal a neuroprotective-effective dose of Factor VIa or a neuroprotective Factor VIa equivalent, with the proviso that the neuropathological condition is not Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis (ALS), denervation atrophy, otosclerosis, stroke, dementia, multiple sclerosis, Huntington's disease, or AIDS-associated encephalopathy.
21-62. (canceled)
Dependencies are inferred from the claim text.