Agents for treating cardiopathy
AssigneeChugai Seiyaku Kabushiki Kaisha
InventorMiyuki Kobara
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Abstract
The present inventors investigated the effects of anti-IL-6 receptor antibodies on improving the condition of infarcted areas in myocardial infarction, and on suppressing left ventricular remodeling after myocardial infarction. As a result, the administration of anti-IL-6 receptor antibodies significantly suppressed the increase of MPO activity in the infarcted area and suppressed myocardial MCP-1 expression in both the infarcted area and the non-infarcted area. Furthermore, echocardiography and histological examinations revealed that cardiac hypertrophy is also suppressed.
Claims24
1-15. (canceled)
A method for treating myocardial infarction in a subject, which comprises the step of administering an IL-6 inhibitor to a subject who has developed myocardial infarction.
A method for suppressing left ventricular remodeling after myocardial infarction in a subject, which comprises the step of administering an IL-6 inhibitor to a subject who has developed myocardial infarction.
24-31. (canceled)
Dependencies are inferred from the claim text.