Method for labeling or treating a biological sample containing biological molecules of interest, in particular nucleic acids

A method for treating a biological sample containing a mixture of biological molecules of interest and of at least one label or labeling precursor of the biological molecules of interest, optionally combined with any ingredient required for the labeling of the biological molecules of interest, consisting in:

• a) providing a reaction vessel,
• b) immobilizing capture molecules, which are capable of binding the label or labeling precursor of the biological molecules of interest, on all or part of the inside surface of the vessel or of a solid support introduced into this vessel,
• c) introducing the biological sample into said reaction vessel,
• d) incubating the content of the reaction vessel,
• e) immobilizing the label or labeling precursor which has not reacted with the biological molecules of interest by binding to the capture molecules, the binding of the label or labeling precursor which is not reacted with the biological molecules of interest, to the capture molecules taking place by means of a covalent bond, and using the labeled biological molecules of interest, i.e. those which are reacted with said label or labeling precursor, for subsequent steps.