PELCAM-1-related molecules compositions kit of parts and associated methods of use
AssigneeThe Johns Hopkins University
InventorsSubroto Chatterjee, Heming Wei
Life of this patent
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Abstract
An isolated polynucleotide coding for platelet endothelial cell adhesion molecule-1 (PECAM-1), and obtainable by amplifying cDNA from total human white blood cells by PCR; peptides encoding PECAM-1 5th Ig-like domain; an antibody against one of the peptides; associated compositions methods and kits of parts.
Claims7
-6. (canceled)
A method to regulate intracellular calcium homeostasis of a human cell, the method comprising administering to the human cell an effective amount of a peptide having amino acid sequence of SEQ ID NO:
- 3 and/or an effective amount of an antibody which bonds to an isolated peptide of SEQ ID NO:
- 3.
Method for inhibiting for inhibiting PECAM-1 dependent trans-endothelial migration of a monocyte, the method comprising administering to the monocyte an effective amount of a peptide having amino acid sequence of SEQ ID NO:
- 3 and/or an effective amount of an antibody which bonds to an isolated peptide of SEQ ID NO:
- 3.
A kit of parts for the regulation of intracellular calcium homeostasis of a human cell, the kit comprising a peptide comprising the sequence SEQ ID NO:
- 3;
- and an antibody which bonds to an isolated peptide having the amino acid sequence of SEQ ID NO:
- 3 the peptide and the antibody to be administered in an effective amount to the human cell thereby regulating the intracellular calcium homeostasis of the human cell.
A kit of parts for inhibiting PECAM-1 dependent trans-endothelial migration of a monocyte, the kit comprising a first peptide comprising the sequence SEQ ID NO:
- 3;
- and an antibody which bonds to an isolated peptide having the amino acid sequence of SEQ ID NO:
- 3 the first peptide and the antibody to be administered in an effective amount to a monocyte thereby inhibiting trans-endothelial migration of the monocyte the trans-endothelial migration dependent on platelet endothelial cell adhesion molecule-1.
Dependencies are inferred from the claim text.