Cationic Polymer for Transporting Nucleic Acids in Cells
AssigneeUniversitäT Regensburg
InventorsAchim Göpferich, Miriam Breunig, Uta Lungwitz, Torsten Blunk
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Abstract
The invention relates to a cationic polymer containing cationic oligomers cross-linkable by fissile linker sequences, wherein said cationic polymers form, together with nucleic acids, polyplexes and can be used for cell transfection and the invention is characterised in that the cationic polymer contains intracellular reductive or enzymatic fissile linker sequences.
Claims7
A cationic polymer at least composed of cationic oligomers, wherein the cationic oligomers are linked via linkers, which are fissile at physiological conditions, wherein the cationic oligomers have at least one positive charge at physiological conditions at a pH-value in a range of from 4 to 8, and wherein the oligomer is composed of at least 23 monomer units.
Dependencies are inferred from the claim text.