Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics
OwnerLynn Doucette-Stamm, David Bush +3inventors
InventorsLynn Doucette-Stamm, David Bush, Qiandong Zeng, Timothy Opperman, Chad Eric Houseweart
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Abstract
The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting from bacterial infection.
Claims20
An isolated nucleic acid encoding a S. pneumoniae surface protein having at least 90% identity to SEQ ID NO:
- 3851.
An isolated nucleic acid having at least 99% identity to SEQ ID NO:
- 1190, wherein the isolated nucleic acid encodes a surface protein.
An isolated nucleic acid selected from the group consisting of:
- a) a nucleic acid having at least 99% identity to SEQ ID NO:
- 1190;
- b) a nucleic acid fully complementary to a nucleic acid having at least 99% identity to SEQ ID NO:
- 1190;
- and
- c) an RNA of a) or b), wherein U is substituted for T;
- wherein the isolated nucleic acid encodes a S. pneumoniae surface protein.
An isolated nucleic acid selected from the group consisting of:
- a) a nucleic acid encoding a S. pneumoniae polypeptide having at least 90% identity to SEQ ID NO:
- 3851;
- b) a nucleic acid fully complementary to a nucleic acid encoding a polypeptide having at least 90% identity to SEQ ID NO:
- 3851;
- and
- c) an RNA of a) or b), wherein U is substituted for T;
- wherein the isolated nucleic acid encodes S. pneumoniae surface protein.
Dependencies are inferred from the claim text.