Method for controlling nad(p)/nad(p)h ratio by oxidoreductase
AssigneeMd Bioalpha Co., Ltd.
InventorsMyung-Gyu Park, Sang-Ku Yoo, In Geun Jo, Taehwan Kwak
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Abstract
Provided is a method capable of effectively treating various diseases associated with energy excess, such as obesity, diabetes, metabolic syndromes, degenerative diseases and mitochondrial dysfunction-related diseases, via elevation of an NAD(P)+/NAD(P)H ratio by increasing an NAD(P)+ concentration in vivo or in vitro through use of NAD(P)H as a substrate or coenzyme by oxidoreductase such as NAD(P)H:quinone oxidoreductase (NQO1), a method of screening a drug for the same and a therapeutic drug.
Claims43
A method for elevating an NAD(P)+/NAD(P)H ratio in vivo or in vitro by regulation or addition of oxidoreductase.
A method for identifying a compound capable of elevating an NAD(P)+/NAD(P)H ratio in vivo or in vitro via NQO1, comprising:
- contacting a candidate compound group with NQO1;
- and
- monitoring an amount or activity of NQO1.
Use of a compound capable of increasing an amount or activity of NQO1 for the manufacture of a medicament for the treatment or prevention of a disease associated with an NAD(P)+/NAD(P)H ratio decrease.
A method for treating or preventing a disease associated with an NAD(P)+/NAD(P)H ratio decrease, comprising administering a therapeutically effective amount of a compound capable of increasing an amount or activity of NQO1 to a subject in need thereof.
An NQO1-enhancing composition comprising (a) a therapeutically effective amount of a compound capable of increasing an amount or activity of NQO1 and (b) a pharmaceutically acceptable carrier, diluent or vehicle, or any combination thereof.
A method for elevating an NAD(P)+/NAD(P)H ratio in vivo, comprising administering NAD(P)+ or a derivative, precursor or prodrug thereof to a subject in need thereof.
A method for inducing improvement of exercise capacity and/or endurance of a subject by artificial elevation of an NAD(P)+/NAD(P)H ratio in vivo.
Dependencies are inferred from the claim text.