B7-h1 and b7-h4 in cancer
AssigneeMayo Foundation for Medical Education and Research
InventorsEugene D. Kwon, John C. Cheville, Amy Krambeck, Susan Kuntz, Robert H. Thompson, Lieping Chen, Haidong Dong, Christine M. Lohse
Life of this patent
Estimating the term…
Abstract
Methods of determining prognosis of a subject with cancer or determining risk of cancer progression by assessing expression of B7-H4, or B7-H1 and B7-H4 in combination.
Claims28
A method of determining the prognosis of a subject with cancer, said method comprising:
- (a) providing a tissue sample from said subject;
- and
- (b) assessing in said tissue sample the presence or absence of expression of B7-H1 and B7-H4, wherein the presence of expression of B7-H1 and B7-H4 in said tissue sample indicates said subject is more likely to die of the cancer than if only B7-H1 or B7-H4 is expressed in said tissue sample.
A method of determining risk of cancer progression in a subject with cancer, said method comprising:
- (a) providing a tissue sample from said subject;
- and
- (b) assessing in said tissue sample the presence or absence of expression of B7-H1 and B7-H4, wherein the presence of expression of B7-H1 and B7-H4 in said tissue sample indicates said subject is at more risk of cancer progression than if only B7-H1 or B7-H4 is expressed in said tissue sample.
An article of manufacture, said article of manufacture comprising a first antibody that binds to a B7-H1 polypeptide and a second antibody that binds to a B7-H4 polypeptide.
A method of determining risk of cancer progression in a subject with cancer, said method comprising:
- (a) providing a tissue sample from said subject;
- and
- (b) assessing in said tissue sample the presence or absence of expression of B7-H4, wherein the presence of expression of B7-H4 in said tissue sample indicates said subject is at more risk of cancer progression than if B7-H4 expression is absent in said tissue sample.
Dependencies are inferred from the claim text.