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US 2009/0214675 A1Published application
4-Chromenonyl-1,4-dihydropyridinecarbonitriles and the use thereof
AssigneeBayer HealthCare LLC
InventorsAlexander Kuhl, Peter Kolkhof, Heike Heckroth, Karl-Heinz Schlemmer, Ingo Flamme, Santiago Figueroa Perez, Heike Gielen-Haertwig, Rolf Grosser, Jens-Kerim Ergüden, Dieter Lang
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Abstract
The present application relates to novel 4-chromenonyl-1,4-dihydropyridinecarbonitriles, processes for their preparation, pharmaceutical compositions containing them, and their use for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.
Claims11
A compound of the formula (I)
- in which
- R1 and R2 are identical or different and are independently of one another (C1-C4)-alkyl, trifluoromethyl, cyclopropyl or cyclobutyl,
- A is a bond or is O,
- R3 is (C3-C7)-cycloalkyl or is (C1-C6)-alkyl which may be substituted by (C3-C7)-cycloalkyl or once to three times by fluorine,
- R4 is hydrogen, halogen, cyano, nitro, trifluoromethyl, (C1-C4)-alkyl or (C1-C4)-alkoxy
- and
- R5 is hydrogen or fluorine,
- or a salt, solvate, or solvate of a salt thereof.
5 more elements
(canceled)
(canceled)
(canceled)
Dependencies are inferred from the claim text.