Loading patent…
AssigneesUniversity of Houston System, Board of Regents of the University of Nebraska, Creighton University
InventorsSunny Edet Ohia, Catherine Atieno Opere, Guilin Zhan, Emmanuel Monjok, Kaustubh Kulkami, Ghislaine E. Kouamou
Estimating the term…
Topical administration of a generator of H2S in biological tissues for the treatment of eye disorders, such as glaucoma. NaHS caused a time-dependent decrease in intrancular pressure in nomotensive, conscious albino rabbits indicating a similar role for H2S in the regulation of aqueous humor dynamics in animals and humans. H2S donors, NaHS and Na2S, inhibited field-stimulated [3H]NE release from porcine isolated iris-ciliary bodies and produced relaxation of pre-contracted iris muscle strips indicating a pharmacological role for H2S in the anterior uvea. The observation that donors of H2S can alter sympathetic neurotransmission and induce an inhibitory action on iris smooth muscle suggests that this gas has the potential to influence several physiological/pathological processes in the eye. The ability of NaHS or Na2S to inhibit [3H]NE release mimics the well-established action some antiglaucoma drugs (e.g. α2-adrenoceptor agonists, prostaglandins) on sympathetic neurotransmission in the anterior uvea and can be used to reduce IOP in animals and humans.
A method of treating an eye having an elevated level of intraocular pressure comprising:
The method of claim l, wherein the effective amount of the solution is about 100 microliter of a solution of 1% (weight/volume) of Na2S, NaHS, or a mixture thereof, in a liquid carrier.
A method of treating an eye having an elevated level of intraocular pressure comprising:
A method of treating an eye having a level of intraocular pressure that is above a desired level, comprising:
Dependencies are inferred from the claim text.