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OwnerJason C. Isenburg, Narendra R. Vyavahare +1inventors
InventorsJason C. Isenburg, Narendra R. Vyavahare, Matthew F. Ogle
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Delivery vehicles for controlled release of connective tissue stabilization agent for the treatment of vascular aneurysms are described. The delivery vehicle generally is combined with a connective tissue stabilization agent to form a therapeutic composition. The treatment of an aneurysm can be achieved through release of connective tissue stabilization agent from the delivery vehicle to the aneurysm. The connective tissue stabilization agent can be collagen stabilization agent, elastin stabilization agent, or a combination thereof. The aneurysm can be treated individually, simultaneously or sequentially with collagen stabilization agent and elastin stabilization agent embedded in separate delivery vehicles.
A therapeutic composition for treatment of aneurysm in a patient, the therapeutic composition comprising connective tissue stabilization agent in combination with a delivery vehicle, wherein the delivery vehicle comprises a hydrogel, nanoparticles, or a combination thereof.
A method of making a therapeutic composition for treatment of aneurysm in a patient, the method comprising,
A method of using a therapeutic composition for the treatment of aneurysm in a patient, the method comprising,
A method for treatment of aneurysm in a patient comprising applying connective tissue stabilization agent in the form of a hydrogel, nanoparticles, or a combination thereof to the aneurysm.
An active agent delivery vehicle comprising a hydrogel and nanoparticles dispersed within the hydrogel, wherein the nanoparticles comprise the active agent and a bioresorbable polymer binder.
Dependencies are inferred from the claim text.