Bone morphogenetic protein 4 and osteogenic devices and pharmaceutical products containing thereof
AssigneeBbs-Bioactive Substitutes Oy
InventorsElli Birr, Mari Ulmanen, Oili Hietala, Marja Juustila, Heli Korkala, Pekka Jalovaara
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Abstract
The present invention relates to reindeer bone formation inducing protein called bone morphogenetic protein 4 (BMP-4) and nucleotide molecules encoding the proteins and host cells expressing the proteins. The present invention relates also to the use of the BMP-4 for treating disorders related to bone and cartilage formation. Osteogenic devices and pharmaceutical compositions containing the proteins are also disclosed.
Claims21
An isolated bone morphogenetic protein 4 (BMP-4), characterized in that it contains the consensus sequence P-Q-R-A/S-R/K-K/R-K/N/R/L-N/K-K/R/S-N/H/S-C-R/K-R-H-S/A-P or C-R/K-R-H-S/A-P-Y-V-D-F-S-D.
13-14. (canceled)
Dependencies are inferred from the claim text.