Methods of Treating alcoholism and alcohol related disorders using combination drug therapy and swellable polymers
AssigneeAlkermes, Inc.
InventorElliot Ehrich
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Abstract
The current invention provides methods of treating alcohol related disorders by providing a sustained release oral drug dosage form comprising a plurality of solid state drugs i.e., baclofen and naltrexone, dispersed in a solid state unitary matrix formed from a combination of swellable polymers. The combination of swellable polymers in a single oral drug dosage form is beneficial in terms of release rate control for combination therapies.
Claims4
A method of treating a subject suffering from an alcohol related disorder comprising the step of orally administering to the stomach of a subject, a controlled release combination of an opioid antagonist and a GABA B agonist in a matrix wherein said matrix comprises a first polymeric matrix and a second polymeric matrix, and wherein the opioid antagonist is dispersed within the first polymeric matrix and the GABA B agonist is dispersed within the second polymeric matrix, said matrix being one that:
- a) swells upon contact with water to promote retention of said oral drug dosage form in the stomach,
- b) releases the opioid antagonist and the GABA B agonist into the gastric fluid by erosion of said first and second polymeric matrix by gastric fluid;
- and
- c) exhibits different erosion rates for each of the first and second polymeric matrices.
Dependencies are inferred from the claim text.