Imaging and Therapeutic Method Using Monocytes
OwnerPhilip S. Low, Andrew R. Hilgenbrinkinventors
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Abstract
The invention relates to a method of treating or diagnosing a disease state mediated by monocytes. The method utilizes a composition comprising a conjugate or complex of the general formula Ab-X wherein the group Ab comprises a ligand that binds to monocytes, and when the conjugate is being used for treatment of the disease state, the group X comprises an immunogen, a cytotoxin, or a compound capable of altering monocyte function, and when the conjugate is being used for diagnosing the disease state, the group X comprises an imaging agent.
Claims21
A method for diagnosing a disease state mediated by monocytes, said method comprising the steps of:
- isolating monocytes from a patient suffering from a monocyte mediated disease state;
- contacting the monocytes with a composition comprising a conjugate or complex of the general formula
- Ab-X
- where the group Ab comprises a ligand that binds to monocytes and the group X comprises an imaging agent;
- and
- quantifying the percentage of monocytes that expresses a receptor for the ligand.
A method for treating a disease state mediated by monocytes, said method comprising the steps of:
- administering to a patient suffering from a monocyte-mediated disease state an effective amount of a composition comprising a conjugate or complex of the general formula
- Ab-X
- where the group Ab comprises a ligand that binds to monocytes and the group X comprises an immunogen, a cytotoxin, or a compound capable of altering monocyte function;
- and
- eliminating the monocyte-mediated disease state.
-27. (canceled)
Dependencies are inferred from the claim text.