Compositions and methods for the treatment of bladder cancer
AssigneeIndevus Pharmaceuticals, Inc.
InventorsJohn Chaber, Petr Kuzma, Agis Kydonieus
Life of this patent
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Abstract
Compositions and methods for the treatment of bladder cancer include intravesical dosage forms of a neoplastic agent and a permeation enhancer. The neoplastic agent may be valrubicin. Pharmaceutical compositions include intravesical dosage forms of a neoplastic agent complexed liposomes. Tight junction openers may be used for the effective delivery of the neoplastic agent.
Claims22
A pharmaceutical composition comprising an effective amount of valrubicin and dimethyl sulfoxide in an intravesical dosage form.
A pharmaceutical composition comprising an effective amount of valrubicin and 2-hydroxy-propyl-β-cyclodextran in an intravesical dosage form.
A pharmaceutical composition comprising:
- a liposomal dosage form comprising an effective amount of liposome-entrapped valrubicin;
- wherein, the liposome comprises at least one liposome forming material selected from the group consisting of:
- phosphatidyl choline and phosphatidyl ethanolamine.
Dependencies are inferred from the claim text.