Process for the Preparation of Strontium Ranelate
AssigneeGlenmark Generics Ltd
InventorsBobba Venkata Siva Kumar, Kosampally Srinivas, Sanjay Anantha Kale, Nitin Sharad Chandra Pradhan
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Abstract
A process for the preparation of strontium ranelate or a hydrate thereof is provided comprising (a) reacting a tetraester compound of Formula II: wherein R, R1, R2, and R3 are independently a linear or branched C1-C6 alkyl group or a substituted or unsubstituted C3-C12 cyclic group, in the presence of a lithium base and in a solvent with an inorganic acid salt of strontium.
Claims31
A process for the preparation of strontium ranelate or a hydrate thereof comprising reacting a tetraester compound of Formula II
- wherein R, R1, R2, and R3 are independently a linear or branched C1-C6 alkyl group or a substituted or unsubstituted C3-C12 cyclic group, in the presence of a lithium base and in a solvent with an inorganic acid salt of strontium.
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A lithium salt of Formula III.
A process for preparing a lithium salt of Formula III:
- the process comprising reacting a tetraester compound of Formula II:
- wherein R, R1, R2, and R3 are independently a linear or branched C1-C6 alkyl group or a substituted or unsubstituted C3-C12 cyclic group, with a lithium base and in a solvent.
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Dependencies are inferred from the claim text.