Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications
OwnerMark H. Schoenfisch, Jae Ho Shin +1inventors
InventorsMark H. Schoenfisch, Jae Ho Shin, Nathan Stasko
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Abstract
The presently disclosed subject matter relates to nitric oxide-releasing particles for delivering nitric oxide, and their use in biomedical and pharmaceutical applications.
Claims69
A nitric oxide-releasing particle, the nitric oxide-releasing particle comprising:
- (a) a nitric oxide donor;
- (b) an interior region having a volume, the volume of the interior region being at least partially filled by a core selected from the group consisting of:
- (i) a metallic cluster;
- (ii) a dendritic network;
- (iii) a co-condensed silica network;
- and
- (iv) a combination thereof;
- and
- (c) an exterior region.
A method of delivering nitric oxide to a subject, the method comprising:
- (a) providing a nitric oxide-releasing particle comprising:
- (i) a nitric oxide donor;
- (ii) an interior region having a volume, the volume of the interior region being at least partially filled by a core selected from the group consisting of:
- (1) a metallic cluster;
- (2) a dendritic network;
- (3) a co-condensed silica network;
- and
- (4) a combination thereof;
- and
- (iii) an exterior region;
- and
- (b) administering an effective amount of the nitric oxide-releasing particle to the subject.
A method of treating a disease state in a subject in need of treatment thereof, the method comprising:
- (a) providing a nitric oxide-releasing particle comprising:
- (i) a nitric oxide donor;
- (ii) an interior region having a volume, the volume of the interior region being at least partially filled by a core selected from the group consisting of:
- (1) a metallic cluster;
- (2) a dendritic network;
- (3) a co-condensed silica network;
- and
- (4) a combination thereof;
- and
- (iii) an exterior region;
- and
- (b) administering an effective amount of the nitric oxide-releasing particle to the subject.
A pharmaceutical formulation comprising:
- (a) a nitric oxide-releasing particle comprising:
- (i) a nitric oxide donor;
- (ii) an interior region having a volume, the volume of the interior region being at least partially filled by a core selected from the group consisting of:
- (1) a metallic cluster;
- (2) a dendritic network;
- (3) a co-condensed silica network;
- and
- (4) a combination thereof;
- and
- (iii) an exterior region;
- and
- (b) a pharmaceutically acceptable carrier.
A nitric oxide-releasing polymeric film comprising an organic polymer and a nitric oxide-releasing particle, said nitric oxide-releasing particle comprising:
- (a) a nitric oxide donor;
- (b) an interior region having a volume, the volume of the interior region being at least partially filled by a core selected from the group consisting of:
- (i) a metallic cluster;
- (ii) a dendritic network;
- (iii) a co-condensed silica network;
- and
- (iv) a combination thereof;
- and
- (c) an exterior region.
A medical device comprising a nitric oxide-releasing polymeric film, wherein the nitric oxide-releasing film comprises an organic polymer and a nitric oxide-releasing particle, the nitric-oxide releasing particle comprising:
- (a) a nitric oxide donor;
- (b) an interior region having a volume, the volume of the interior region being at least partially filled by a core selected from the group consisting of:
- (i) a metallic cluster;
- (ii) a dendritic network;
- (iii) a co-condensed silica network;
- and
- (iv) a combination thereof;
- and
- (c) an exterior region.
A detergent comprising a nitric oxide-releasing particle, said nitric oxide-releasing particle comprising:
- (a) a nitric oxide donor;
- (b) an interior region having a volume, the volume of the interior region being at least partially filled by a core selected from the group consisting of:
- (i) a metallic cluster;
- (ii) a dendritic network;
- (iii) a co-condensed silica network;
- and
- (iv) a combination thereof;
- and
- (c) an exterior region.
Dependencies are inferred from the claim text.