Biomaterials having nanoscale layers and coatings
AssigneeWashington University in St. Louis
InventorsDonald Elbert, Megan Kaneda, Evan Scott, Brad Wacker, Shannon Alford
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Abstract
The invention generally relates to substrates and surfaces having substrates. Generally speaking, the substrates may be thinly layered substrates, and the surfaces may comprise thinly layered substrates. Additionally, the substrates may comprise a multifunctional water soluble polymer and a lipoprotein and the surfaces may comprise a multifunctional water soluble polymer and a lipoprotein.
Claims68
A substrate, the substrate having a plurality of cross-linked, distinctly-formed layers, the distinctly-formed layers comprising multifunctional, water soluble polymer layers and protein layers, the protein having at least one lipid binding site, each protein layer being disposed between two layers of the water soluble polymer, whereby each protein layer cross-links the water soluble polymer layers together to form the plurality of distinctly-formed layers.
The substrate of claim 18, wherein the added amino acid residue is cysteine.
A surface, the surface being coated with a plurality of cross-linked, distinctly-formed layers, the distinctly-formed layers comprising multifunctional, water soluble polymer layers and protein layers, the protein having at least one lipid binding site, each protein layer being disposed between two layers of the water soluble polymer, whereby each protein layer cross-links the water soluble polymer layers together to form the plurality of distinctly-formed layers.
A substrate, the substrate comprising a multifunctional water soluble polymer layer and a recombinant high density lipoprotein, whereby the recombinant high density lipoprotein cross-links the water soluble polymer to form the substrate.
A surface, the surface being coated with a substrate comprising a multifunctional water soluble polymer layer and a recombinant high density lipoprotein, whereby the recombinant high density lipoprotein cross-links the water soluble polymer.
Dependencies are inferred from the claim text.