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US 2009/0214603 A1Published application
Synthetic peptides
AssigneeUniversity of Louisville Research Foundation, Inc.
InventorsDonald R. Demuth, Carlo Amorin Daep
Life of this patent
Estimating the term…
Abstract
The present invention provides streptococcal SspB Adherence Region (BAR) peptides, nucleic acids encoding the BAR peptides, and methods of using the BAR peptides, and methods of screening BAR peptide mimetics.
Claims20
A peptide of Formula I (SEQ ID NO:
- 53):
- R18-R1-R2-Val-R3-R4-Leu-Leu-R5-R6-R7-Ile-R8-R9-Lys-R10-R19
- wherein
- R1 is 0-1 Cys or ornithine residue;
- R2 is 1-3 Lys residues;
- R3 is any amino acid residue except a Pro residue;
- R4 is any amino acid residue except a Pro residue;
- R5 is 1-3 Lys residues;
- R6 is 1-10 amino acid residues;
- R7 is any amino acid except Asp, Glu, Gly or Pro;
- R8 is any amino acid residue except Ala, Asp, Gly, His, Ile, Pro, Trp or Tyr;
- R9 is a Val, Ile, Phe, or Trp residue;
- R10 is 0-1 Cys residue;
- R18 is 0 amino acids or R12-R11-Pro-,
- wherein R1, is 0-3 amino acids, wherein the amino acid residues are not Gly or Pro;
- and
- R12 is 0-1 Cys residues;
- and
- R19 is -R13-R14-R15-R16-R17,
- wherein R13 is 0-1 is Gly residue;
- R14 is 0-1 Ala residue;
- R15 is 0-1 Phe residue;
- R16 is 0-1 Gln residue;
- and
- R17 is 0-1 Cys residue.
22 more elements
Dependencies are inferred from the claim text.