Methods and compositions for gastric resistant oral formulations for intestinal delivery

A method of formulating a gastric resistant oral formulation for intestinal delivery comprising:

• emulsifying a bioactive pharmaceutical, an enhancer and a modulator in an emulsifier to form an inner core region;
• forming an outer membrane region comprising droplets of calcium alginate;
• microinjecting the inner core region into the outer membrane region;
• adding polymerization additives to the calcium alginate for membrane stability;
• submerging the oral formulation into calcium chloride solution;
• and
• drying the oral formulation.

A method of mammalian administration of an oral formulation resistant to

• gastric disintegration, comprising:
• administering an oral formulation to a patient in need thereof;
• causing the oral formulation to enter the gastric cavity;
• bypassing gastric disintegration of the oral formulation;
• undergoing dissolution of an outer membrane region of the oral formulation upon encountering small intestine digestive enzymes;
• releasing a therapeutically effective amount of solubilized bioactive pharmaceutical from an inner core region;
• translocating the bioactive pharmaceutical across intestinal mucosa;
• and
• absorbing the bioactive pharmaceutical into the blood.