Adjuvant composition comprising aluminium phosphate and 3D-MPL
OwnerDerek O'Haganinventor
Life of this patent
Estimating the term…
Abstract
An immunogenic composition comprising: (i) an antigen; (ii) an aluminum phosphate adjuvant; and (iii) a 3-O-deacylated monophosphoryl lipid A adjuvant. Components (ii) and (iii) can also be used as a separate adjuvant system. Various features of the compositions are disclosed, including that at least 50% of the 3-O-deacylated monophosphoryl lipid A adjuvant should be adsorbed to the aluminum phosphate adjuvant. The adjuvant mixture is particularly useful with hepatitis B virus surface antigen.
Claims26
An adjuvant composition comprising:
- (i) an aluminum phosphate adjuvant;
- and (ii) a 3-O-deacylated monophosphoryl lipid A adjuvant, characterised in that at least 50% of the 3-O-deacylated monophosphoryl lipid A is adsorbed to the aluminum phosphate adjuvant.
An immunogenic composition comprising:
- (i) an aluminum phosphate adjuvant;
- (ii) a 3-O-deacylated monophosphoryl lipid A adjuvant;
- and (iii) an antigen, characterised in that at least 50% of the 3-O-deacylated monophosphoryl lipid A is adsorbed to the aluminum phosphate adjuvant.
A method for raising an immune response in a patient comprising administering to the patient a composition comprising:
- (i) an antigen;
- (ii) an aluminum phosphate adjuvant;
- and (iii) a 3-O-deacylated monophosphoryl lipid A adjuvant, wherein at least 50% of the 3-O-deacylated monophosphoryl lipid A is adsorbed to the aluminum phosphate adjuvant.
Dependencies are inferred from the claim text.