Vaccines against aids comprising cmv/r-nucleic acid constructs
OwnerGary J. Nabel, Yue Huang +7inventors
InventorsGary J. Nabel, Yue Huang, Zengguang Wang, Ling Xu, Bimal Chakrabarti, Lan Wu, Zhi-yong Yang, Jason G.D. Gall, C. Richter King
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Abstract
The present disclosure provides compositions for eliciting an immune response, including a prophylactic immune response, against human immunodeficiency virus. The composition includes nucleic acid constructs encoding HIV antigenic polypeptides of multiple clades or strains. Methods for eliciting an immune response by administering the composition to a subject are also provided.
Claims36
A composition capable of eliciting an immune response against HIV in an immunocompetent subject, the composition comprising:
- a plurality of different nucleic acid constructs, each nucleic acid construct comprising a polynucleotide sequence encoding an HIV antigenic polypeptide operably linked to a CMV/R transcription control sequence,
- wherein the plurality of nucleic acid constructs encode antigenic polypeptides of a plurality of HIV clades or strains.
A composition capable of eliciting an immune response against HIV in an immunocompetent subject, the composition comprising:
- a plurality of different nucleic acid constructs, each nucleic acid construct comprising a polynucleotide sequence encoding a single HIV antigenic polypeptide, wherein the plurality of nucleic acid constructs encode antigenic polypeptides of a plurality of HIV clades or strains.
The composition of claim in 3, further comprising a plurality of additional nucleic acid constructs, each of which additional nucleic acid constructs comprises a polynucleotide sequence encoding an Env polypeptide of a different HIV clade or strain.
A composition capable of eliciting an immune response against HIV in an immunocompetent subject, the composition comprising:
- a plurality of different nucleic acid constructs, each nucleic acid construct comprising a polynucleotide sequence encoding a single HIV antigen operably linked to a transcription control sequence.
An isolated or recombinant nucleic acid comprising a polynucleotide sequence encoding an HIV antigenic polypeptide operably linked to a CMV/R transcription regulatory sequence.
Dependencies are inferred from the claim text.