Annexin II and uses thereof
OwnerElena Feinstein, Igor Mett +1inventors
InventorsElena Feinstein, Igor Mett, Michael Shtutman
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Abstract
The present invention relates to the field of diagnosis and treatment of neurodegenerative diseases, ischemic events, and central nervous system injury, and provides compositions and methods for alleviation or reduction of the symptoms and signs associated with damaged neuronal tissues whether resulting from tissue trauma, or from chronic or acute degenerative changes. The present invention in particular relates to the discovery that the expression of Annexin II is involved in apoptosis induced by oxidative stress, and that anti-sense Annexin II RNA and Annexin II siRNA protected the cells from this apoptosis. Thus Annexin II inhibitors prevent the damage caused by said ischemic event.
Claims20
A method of treating a patient suffering from a neurodegenerative disease or a central nervous system disorder, comprising administering to the patient a pharmaceutical composition comprising a therapeutically effective amount of an Annexin II inhibitor, so as to thereby treat the patient.
A method for treating a patient who has suffered an injury to the central nervous system, comprising administering to the patient a pharmaceutical composition comprising a therapeutically effective amount of an Annexin II inhibitor in a dosage and over a period of time so as to thereby treat the patient.
A compound having the structure
- 5′(N)x-Z 3′ (antisense strand)
- 3′Z′-(N′)y5′ (sense strand)
- wherein each N and N′ is a ribonucleotide which may be modified or unmodified in its sugar residue and (N)x and (N′)y is oligomer in which each consecutive N or N′ is joined to the next N or N′ by a covalent bond;
- wherein each of x and y is an integer between 19 and 40;
- wherein each of Z and Z′ may be present or absent, but if present is dTdT and is covalently attached at the 3′ terminus of the strand in which it is present;
- and wherein the sequence of (N)x comprises an antisense sequence to cDNA of Annexin II.
Dependencies are inferred from the claim text.