Anti-ephrinb2 antibodies and methods using same
AssigneeGenentech, Inc.
InventorsYan Wu, Minhong Yan
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Abstract
The invention provides anti-EphrinB2 antibodies, and compositions comprising and methods of using these antibodies.
Claims48
An isolated anti-EphrinB2 antibody comprising:
- (a) at least one, two, three, four or five hypervariable region (HVR) sequences selected from the group consisting of:
- (i) HVR-L1 comprising sequence A1-A11, wherein A1-A11 is RASQDVSTAVA (SEQ ID NO:
- 6)
- (ii) HVR-L2 comprising sequence B1-B7, wherein B1-B7 is SASFLYS (SEQ ID NO:
- 8)
- (iii) HVR-L3 comprising sequence C1-C9, wherein C1-C9 is EQTDSTPPT (SEQ ID NO:12)
- (iv) HVR-H1 comprising sequence D1-D10, wherein D1-D10 is GFTVSSGWIH (SEQ ID NO:2)
- (v) HVR-H2 comprising sequence E1-E18, wherein E1-E18 is AVIFHNKGGTDYADSVKG (SEQ ID NO:4) and
- (vi) HVR-H3 comprising sequence F1-F14, wherein F1-F14 is ARTSAWAQLGAMDY (SEQ ID NO:5);
- and
- (b) at least one variant HVR, wherein the variant HVR sequence comprises modification of at least one residue of the sequence depicted in SEQ ID NOs:1-12.
An isolated anti-EphrinB2 antibody comprising one, two, three, four, five or six HVRs, wherein each HVR comprises, consists or consists essentially of a sequence selected from the group consisting of SEQ ID NOs:
- 1-12, and wherein SEQ ID NO:6 or 7 correspond to an HVR-L1, SEQ ID NO:8 or 9 correspond to an HVR-L2, SEQ ID NO:
- 10, 11 or 12 correspond to an HVR-L3, SEQ ID NO:
- 1 or 2 correspond to an HVR-H1, SEQ ID NO:3 or 4 correspond to an HVR-H2, and SEQ ID NO:5 corresponds to an HVR-H3.
A method for detection of EphrinB2, the method comprising detecting EphrinB2-anti-EphrinB2 antibody complex in a biological sample.
A method for diagnosing a disorder associated with EphrinB2 expression, the method comprising detecting EphrinB2-anti-EphrinB2 antibody complex in a biological sample from a patient having or suspected of having the disorder.
Dependencies are inferred from the claim text.