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US 2009/0214558 A1Published application
NOVEL MAdCAM ANTIBODIES
AssigneePfizer Inc.
InventorNicholas Pullen
Life of this patent
Estimating the term…
Abstract
The invention provides new, improved anti-MAdCAM antibodies. Uses of these antibodies in medicine are also included, in particular for the treatment of inflammatory conditions such as inflammatory bowel disease.
Claims14
A monoclonal antibody that specifically binds MAdCAM, or antigen-binding portion thereof, selected from the group consisting of:
- (a) an antibody comprising the variable region of the heavy chain of 6.22.2-mod_V (SEQ ID NO:
- 2) with or without signal sequence;
- (b) an antibody comprising the variable region of the light chain of 6.34.2-mod_SSQ, 6.34.2-mod_QT, or 6.34.2-mod_SSQ,QT (SEQ ID NOs:
- 8, 10, 12) with or without signal sequence;
- (c) an antibody comprising the variable region of the light chain of 6.67.1-mod_Y, 6.67.1-mod_TΔP, or 6.67.1-mod_Y,TΔP (SEQ ID NOs:
- 16, 18, 20) with or without signal sequence;
- (d) an antibody comprising the variable region of the heavy chain of 6.77.1-mod_ΔS (SEQ ID NO:
- 22) with or without signal sequence;
- (e) an antibody comprising the variable region of the heavy chain of 7.16.6 (SEQ ID NO:
- 26), or 7.16.6_L (SEQ ID NO:
- 28) with or without signal sequence;
- or
- (f) an antibody comprising the variable region of the light chain of 7.16.6_V, 7.16.6_S, or 7.16.6_VS (SEQ ID NOs:
- 30, 32, 34) with or without signal sequence;
- (g) an antibody comprising the variable region of the light chain of 7.16.6_V, 7.16.6_S, or 7.16.6_VS (SEQ ID NOs:
- 30, 32, 34) with or without signal sequences and the variable region of the heavy chain of 7.16.6 (SEQ ID NO:
- 26) or 7.16.6_L (SEQ ID NO:
- 28) with or without signal sequence;
- (h) an antibody comprising the variable region of the heavy chain of 9.8.2_ΔRGAYH,D (SEQ ID NO:
- 36) with or without signal sequence;
- and
- (i) an antibody comprising the variable region of the light chain of 9.8.2-mod (SEQ ID NO:
- 38) with or without signal sequence.
20 more elements
A method for treating inflammatory disease in a patient comprising administering a therapeutically effective amount of a monoclonal antibody that specifically binds MAdCAM, or antigen-binding portion thereof, selected from the group consisting of:
- (a) an antibody comprising the variable region of the heavy chain of 6.22.2-mod_V (SEQ ID NO:
- 2) with or without signal sequence;
- (b) an antibody comprising the variable region of the light chain of 6.34.2-mod_SSQ, 6.34.2-mod_QT, or 6.34.2-mod_SSQ,QT (SEQ ID NOs:
- 8, 10, 12) with or without signal sequence;
- (c) an antibody comprising the variable region of the light chain of 6.67.1-mod_Y, 6.67.1-mod_TΔP, or 6.67.1-mod_Y,TΔP (SEQ ID NOs:
- 16, 18, 20) with or without signal sequence;
- (d) an antibody comprising the variable region of the heavy chain of 6.77.1-mod_AS (SEQ ID NO:
- 22) with or without signal sequence;
- (e) an antibody comprising the variable region of the heavy chain of 7.16.6 (SEQ ID NO:
- 26), or 7.16.6_L (SEQ ID NO:
- 28) with or without signal sequence;
- or
- (f) an antibody comprising the variable region of the light chain of 7.16.6_V, 7.16.6_S, or 7.16.6_VS (SEQ ID NOs:
- 30, 32, 34) with or without signal sequence;
- (g) an antibody comprising the variable region of the light chain of 7.16.6_V, 7.16.6_S, or 7.16.6_VS (SEQ ID NOs:
- 30, 32, 34) with or without signal sequences and the variable region of the heavy chain of 7.16.6 (SEQ ID NO:
- 26) or 7.16.6_L (SEQ ID NO:
- 28) with or without signal sequence;
- (h) an antibody comprising the variable region of the heavy chain of 9.8.2_ΔRGAYH,D (SEQ ID NO:
- 36) with or without signal sequence;
- and
- (i) an antibody comprising the variable region of the light chain of 9.8.2-mod (SEQ ID NO:
- 38) with or without signal sequence.
20 more elements
A pharmaceutical composition comprising a therapeutically effective amount of a monoclonal antibody that specifically binds MAdCAM, or antigen-binding portion thereof, selected from the group consisting of:
- (a) an antibody comprising the variable region of the heavy chain of 6.22.2-mod_V (SEQ ID NO:
- 2) with or without signal sequence;
- (b) an antibody comprising the variable region of the light chain of 6.34.2-mod_SSQ, 6.34.2-mod_QT, or 6.34.2-mod_SSQ,QT (SEQ ID NOs:
- 8, 10, 12) with or without signal sequence;
- (c) an antibody comprising the variable region of the light chain of 6.67.1-mod_Y, 6.67.1-mod_TAP, or 6.67.1-mod_Y,TΔP (SEQ ID NOs:
- 16, 18, 20) with or without signal sequence;
- (d) an antibody comprising the variable region of the heavy chain of 6.77.1-mod_AS (SEQ ID NO:
- 22) with or without signal sequence;
- (e) an antibody comprising the variable region of the heavy chain of 7.16.6 (SEQ ID NO:
- 26), or 7.16.6_L (SEQ ID NO:
- 28) with or without signal sequence;
- or
- (f) an antibody comprising the variable region of the light chain of 7.16.6_V, 7.16.6_S, or 7.16.6-VS (SEQ ID NOs:
- 30, 32, 34) with or without signal sequence;
- (g) an antibody comprising the variable region of the light chain of 7.16.6_V, 7.16.6_S, or 7.16.6_VS (SEQ ID NOs:
- 30, 32, 34) with or without signal sequences and the variable region of the heavy chain of 7.16.6 (SEQ ID NO:
- 26) or 7.16.6_L (SEQ ID NO:
- 28) with or without signal sequence;
- (h) an antibody comprising the variable region of the heavy chain of 9.8.2_ΔRGAYH,D (SEQ ID NO:
- 36) with or without signal sequence;
- and
- (i) an antibody comprising the variable region of the light chain of 9.8.2-mod (SEQ ID NO:
- 38) with or without signal sequence.
20 more elements
Dependencies are inferred from the claim text.