Identification of Surface-Associated Antigens for Tumor Diagnosis and Therapy
AssigneeGanymed Pharamaceuticals AG
InventorsUgur Sahin, Özlem Türeci, Michael Koslowski, Gerd Helftenbein, Dirk Usener, Volker Schlüter
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Abstract
The invention relates to identifying tumor-associated genetic products and encoding nucleic acids thereof. A therapy and diagnosis of diseases in which the tumor-associated genetic products are aberrantly expressed, proteins, polypeptides and peptides which are expressed in association with tumor and the encoding nucleic acids for said proteins, polypeptides and peptides are also disclosed.
Claims50
-114. (canceled)
An isolated nucleic acid that encodes for a tumor-associated antigen or a portion thereof, and which is selected from the group consisting of:
- (a) a nucleic acid which comprises a nucleic acid sequence selected from the group consisting of SEQ ID NOs:
- 13, 1, 5, 9, 17, 21, 25, 29, 33, 37, 41, 45, 49, 53, 57, 61, 65, 69, 73, 77, 81, 85, 89, 93, 97, 101, 105, 109, 113, 117, 121, 125, 129, 133, 137, 141, 145, 149, 153, 157, 161, 165, 169, 173, 175, 179, 183, 187, 191, 195, 199, 203, 207, 211, 215, 219, 223, 227, 231, 235, 239, 243, 247, 251, 255, 259, 263, 267, 269, 271, 273, 275, 277, 279, 309, 313, and a portion thereof,
- (b) a nucleic acid that hybridizes with the nucleic acid of (a) under stringent conditions,
- (c) a nucleic acid that is degenerate with respect to the nucleic acid of (a) or (b), and
- (d) a nucleic acid that is complementary to the nucleic acid of (a), (b) or (c).
An isolated nucleic acid selected from the group consisting of:
- (a) a nucleic acid that comprises a nucleic acid sequence selected from the group consisting of SEQ ID NOs:
- 13, 1, 5, 9, 17, 21, 25, 29, 33, 37, 41, 45, 49, 53, 57, 61, 65, 69, 73, 77, 81, 85, 89, 93, 97, 101, 105, 109, 113, 117, 121, 125, 129, 133, 137, 141, 145, 149, 153, 157, 161, 165, 169, 173, 175, 179, 183, 187, 191, 195, 199, 203, 207, 211, 215, 219, 223, 227, 231, 235, 239, 243, 247, 251, 255, 259, 263, 267, 269, 271, 273, 275, 277, 279, 309, 313, and a portion thereof,
- (b) a nucleic acid that hybridizes with the nucleic acid of (a) under stringent conditions,
- (c) a nucleic acid that is degenerate with respect to the nucleic acid of (a) or (b), and
- (d) a nucleic acid that is complementary to the nucleic acid of (a), (b) or (c).
An isolated polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 14, 2, 6, 10, 18, 22, 26, 30, 34, 38, 42, 46, 50, 54, 58, 62, 66, 70, 74, 78, 82, 86, 90, 94, 98, 102, 106, 110, 114, 118, 122, 126, 130, 134, 138, 142, 146, 150, 154, 158, 162, 166, 170, 174, 176, 180, 184, 188, 192, 196, 200, 204, 208, 212, 216, 220, 224, 228, 232, 236, 240, 244, 248, 252, 256, 260, 264, 268, 270, 272, 274, 276, 278, 280-308, 310, 314, and a portion thereof.
Dependencies are inferred from the claim text.