Antigenic Epitopes Of Inteleukin-21, Related Antibodies And Their Use In Medical Field
OwnerGiovanni Monteleoneinventor
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Abstract
The present invention relates to antigenic epitopes of interleukin-21, related antibodies and their use in medical field, in particular for the treatment of immune-inflammatory diseases characterized by an enhanced production and/or activity of IL-21, such as for example chronic inflammatory bowel diseases (IBD), celiac disease and psoriasis.
Claims17
Use of the antibodies specific and selective for at least one of the following antigenic epitopes:
- KMI HQH LSS RTH GSE DS;
- (SEQ ID NO:
- 1)
- NVS IKK LKR KPP STN;
- (SEQ ID NO:
- 2)
- LGT LVH KSS SQG QDR;
- (SEQ ID NO:
- 3)
- TNA GRR QKH RLT CPS;
- (SEQ ID NO:
- 4)
- CDS YEK KPP KEF LER;
- (SEQ ID NO:
- 5)
- CFQ KAQ LKS ANT GNN E;
- (SEQ ID NO:
- 6)
- for the preparation of a medicament for the treatment of Th1-mediated immune-inflammatory diseases associated with an altered IL-21 expression.
Use of the antibodies specific and selective for at least one of the following antigenic epitopes:
- KMI HQH LSS RTH GSE DS;
- (SEQ ID NO:
- 1)
- NVS IKK LKR KPP STN;
- (SEQ ID NO:
- 2)
- LGT LVH KSS SQG QDR;
- (SEQ ID NO:
- 3)
- TNA GRR QKH RLT CPS;
- (SEQ ID NO:
- 4)
- CDS YEK KPP KEF LER;
- (SEQ ID NO:
- 5)
- CFQ KAQ LKS ANT GNN E;
- (SEQ ID NO:
- 6)
- for the in-vitro diagnosis of Th1-mediated immune-inflammatory disease associated with an altered IL-21 expression.
Diagnostic kit comprising at least one of the antibodies specific and selective for at least one of the following antigenic epitopes and/or the same epitopes:
- KMI HQH LSS RTH GSE DS;
- (SEQ ID NO:
- 1)
- NVS IKK LKR KPP STN;
- (SEQ ID NO:
- 2)
- LGT LVH KSS SQG QDR;
- (SEQ ID NO:
- 3)
- TNA GRR QKH RLT CPS;
- (SEQ ID NO:
- 4)
- CDS YEK KPP KEF LER;
- (SEQ ID NO:
- 5)
- CFQ KAQ LKS ANT GNN E.
- (SEQ ID NO:
- 6)
An isolated antibody that is specifically reactive with at least one of:
- amino acids 146-162 of human IL-21 (SEQ ID NO:
- 1);
- amino acids 97-111 of human IL-21 (SEQ ID NO:
- 2);
- amino acids 20-34 of human IL-21 (SEQ ID NO:
- 3);
- amino acids 110-124 of human IL-21 (SEQ ID NO:
- 4);
- amino acids 125-139 of human IL-21 (SEQ ID NO:
- 5);
- or
- amino acids 78-93 of human IL-21 (SEQ ID NO:
- 6).
(canceled)
Dependencies are inferred from the claim text.