Binding member towards pneumolysin
OwnerAnders Per Sorensen, Thomas Lars Benfield +2inventors
InventorsAnders Per Sorensen, Thomas Lars Benfield, Jens Dilling Lundgren, Thomas D. Kempe
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Abstract
The present invention relates to an anti-haemolytic binding member comprising at least one binding domain capable of specifically binding Pneumolysin, in particular to a binding member having at least two biding domains, to the use of said binding members in diagnostic methods as well as for treatment. In a preferred embodiment the binding member is an antibody, such as a human antibody, or a fragment thereof, and it may also be a bispecific antibody.
Claims51
An isolated anti-haemolytic binding member comprising at least one binding domain capable of specifically binding Pneumolysin, wherein said binding domain recognizes an epitope in the N-terminal part of Pneumolysin corresponding to amino acid 1-436 of SEQ ID NO:
- 11.
A Pneumolysin peptide, fragment or variant thereof, comprising an amino acid sequence selected from SEQ ID NO 27, 28, 27, 30, 31, 32, 33, 34, 35e and 36.
A vaccine composition comprising a Pneumolysin peptide, wherein the Pneumolysin peptide, comprises an amino acid sequence or variant thereof selected from SEQ ID NO 27, 28, 29, 30, 31, 32, 33, 34, 35 and 36.
Dependencies are inferred from the claim text.