Novel therapeutic targets in cancer

A method of diagnosing cancer in a patient comprising detecting the presence of differential expression of a gene in a patient sample, said gene comprising a nucleotide sequence selected from the group consisting of SEQ ID NO:

• 4, 10, 18, 26, 34, 44, 50, 60, 82, 88, 112, 122, 128, 136, 154, and 170, wherein the presence of differential expression of the gene in said sample is indicative of a patient who has cancer.

A method of diagnosing cancer comprising:

• a) determining the expression of one or more genes comprising a nucleic acid sequence selected from the group consisting of SEQ ID NO:
• 4, 10, 18, 26, 34, 44, 50, 60, 82, 88, 112, 122, 128, 136, 154, and 170, in a first tissue type of a first individual;
• and b) comparing the gene expression in a) to expression of the gene in a control, wherein a difference between the expression of the gene in the first tissue type of the first individual compared to expression of the gene in the control indicates that the first individual has cancer.

A method for inhibiting the activity of a protein, wherein said protein is encoded by a nucleic acid comprising a nucleic acid sequence selected from the group consisting of SEQ ID NO:

• 5, 11, 13, 19, 27, 29, 35, 37, 39, 45, 51, 53, 55, 61, 63, 65, 67, 69, 71, 73, 75, 83, 89, 91, 93,95,97,99, 101, 103, 105, 107, 113, 115, 117, 123, 129, 137, 139, 141, 143, 145, 147, 149, 155, 157, 159, 161, 163, 165, 171, and 173, said method comprising binding an inhibitor to said protein.

A method of treating cancer comprising administering to a patient an inhibitor of a protein, wherein said protein is encoded by a nucleic acid comprising a nucleic acid sequence selected from the group consisting of SEQ ID NO:

• 4, 10, 18, 26, 34, 44, 50, 60, 82, 88, 112, 122, 128, 136, 154, and 170.

A method of neutralizing the effect of a protein, wherein said protein is encoded by a nucleic acid comprising a nucleic acid sequence selected from the group consisting of SEQ ID NO:

• 4, 10, 18, 26, 34, 44, 50, 60, 82, 88, 112, 122, 128, 136, 154, and 170, the method comprising contacting an agent specific for said protein with said protein in an amount sufficient to effect neutralization.

An isolated antibody which specifically binds to a polypeptide having a sequence selected from the group consisting of a sequence selected from the group consisting of SEQ ID NO:

• 6, 12, 14, 20, 28, 30, 36, 38, 40, 46, 52, 54, 56, 62, 64, 66, 68, 70, 72, 74, 76, 84, 90, 92, 94, 96,98,100,102,104,106,108,114,116,118,124,130,138,140,142,144,146,148,150,156, 158, 160, 162, 164, 166, 172, and 174.