Combination Therapy Using Anti-EGFR and Anti-HER2 Antibodies
AssigneeL'instut National De La Sante Et De La Recherche Medicale
InventorsStephen D. Gillies, David Azria, Christel Larbouret, Andre Pelegrin
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Abstract
The invention relates to the combined use of anti-EGFR antibodies and anti-Her2 antibodies for the treatment of cancer, especially suitable for cancer expressing high levels of the EGFR type and low levels of HER2. The invention refers in particular monoclonal antibody “trastuzumab” (HERCEPTIN®) directed against the HER2 receptors the efficacy of which can be significantly increased in vivo when combined with monoclonal antibody “matuzumab” (hmAB 425, EMD 72000) directed against EGF receptors. The combination treatment is suitable for patients suffering from cancer having said receptor profile, preferably pancreatic cancer.
Claims25
1-21. (canceled)
A method for treating cancer that expresses HER2 and EGFR in an individual, wherein said cancer in said individual expresses HER2 in levels that are not sufficient to respond significantly to an anti-HER2 antibody, when given alone to the individual, the method comprising administering to the individual an anti-HER2 antibody, which, when given alone, does not or not significantly inhibit HER2 dimerization and/or HER2/EGFR heterodimerization, and an anti-EGFR antibody, which, when given alone, significantly inhibits EGFR dimerization and/or EGFR/HER2 heterodimerization.
A method for improving the efficacy of the treatment of cancer that expresses HER2 and EGFR with an anti-HER2 antibody, wherein said cancer expresses HER2 in levels that are not sufficient to respond significantly to said anti-HER2 antibody treatment alone;
- the method comprising administering to an individual an anti-HER2 antibody, which, when given alone, does not or not significantly inhibit HER2 dimerization and/or HER2/EGFR heterodimerization, and an anti-EGFR antibody, which, when given alone, significantly inhibits EGFR dimerization and/or EGFR/HER2 heterodimerization.
Dependencies are inferred from the claim text.