Protein involved in cancer
OwnerAlasdair Craig Stampsinventor
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Abstract
The present invention relates to new uses of PSK-1 in the diagnosis, screening, treatment and prophylaxis of ovarian and lung cancer. The invention also provides compositions comprising PSK-1, including vaccines, antibodies that are immunospecific for PSK-1 and agents which interact with or modulate the expression or activity of PSK-1 or which modulate the expression of the nucleic acid which codes for PSK-1.
Claims31
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A method for the treatment and/or prophylaxis of cancer comprising administering a therapeutically effective amount of an agent which interacts with or modulates the expression or activity of a PSK-1 polypeptide.
A method for the treatment and/or prophylaxis of cancer comprising administering a therapeutically effective amount of a composition comprising a PSK-1 polypeptide.
A method of screening for anti-cancer agents that interact with a PSK-1 polypeptide, said method comprising:
- (a) contacting said polypeptide with a candidate agent;
- and
- (b) determining whether or not the candidate agent interacts with said polypeptide.
A method of screening for anti-cancer agents that modulate the expression or activity of a PSK-1 polypeptide comprising:
- (i) comparing the expression or activity of said polypeptide in the presence of a candidate agent with the expression or activity of said polypeptide in the absence of the candidate agent or in the presence of a control agent;
- and
- (ii) determining whether the candidate agent causes the expression or activity of said polypeptide to change.
A method of screening for and/or diagnosis or prognosis of cancer in a subject, and/or monitoring the effectiveness of cancer therapy, which comprises the step of detecting and/or quantifying in a biological sample obtained from said subject, the expression of a PSK-1 polypeptide.
A diagnostic kit comprising a capture reagent specific for a PSK-1 polypeptide, reagents and instructions for use.
Dependencies are inferred from the claim text.