B-cell reduction using cd37-specific and cd20-specific binding molecules

A humanized CD37-specific immunoglobulin binding molecule comprising:

• (a) human light chain framework regions, a light chain CDR1 comprising an amino acid sequence of SEQ ID NO:62 or a variant thereof in which one or two amino acids of SEQ ID NO:62 have been changed, a light chain CDR2 comprising an amino acid sequence of SEQ ID NO:64 or a variant thereof in which one or two amino acids of SEQ ID NO:64 have been changed, and a light chain CDR3 comprising an amino acid sequence of SEQ ID NO:66 or a variant thereof in which one or two amino acids of SEQ ID NO:66 have been changed;
• and
• (b) human heavy chain framework regions, a heavy chain CDR1 comprising an amino acid sequence of SEQ ID NO:63 or a variant thereof in which one or two amino acids of SEQ ID NO:63 have been changed, a heavy chain CDR2 comprising an amino acid sequence of SEQ ID NO:65 or a variant thereof in which one or two amino acids of SEQ ID NO:65 have been changed, and a heavy chain CDR3 comprising an amino acid sequence of SEQ ID NO:69 or a variant thereof in which one or two amino acids of SEQ ID NO:69 have been changed;
• wherein the humanized binding molecule competes with monoclonal antibody G28-1 for binding with human CD37.