Kinesin inhibitors

A compound of formula (I):

• wherein
• X is O or S;
• each of D, E, F, G, I, J, T, U, V, W, Y, and Z, independently, is C, C(Ra1), C(Ra1Ra2);
• N,N(Ra1), O, or S;
• each of Ra1 and Ra2, independently, being H, halo, CN, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C20 cycloalkyl, C3-C20 cycloalkenyl, C3-C20 heterocycloalkyl, C3-C20 heterocycloalkenyl, aryl, heteroaryl, COOR, OCOR, N(RR′), C(O)—N(RR′), or N(R)—C(O)R′;
• in which each of R and R′, independently, is H, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C20 cycloalkyl, C3-C20 cycloalkenyl, C3-C20 heterocycloalkyl, C3-C20 heterocycloalkenyl, aryl, or heteroaryl;
• each independently, is a single bond or a double bond;
• each of A and B, independently, is aryl or heteroaryl;
• in which aryl or heteroaryl is optionally substituted by 1, 2, or 3 substituents selected from the group consisting of halo, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C20 cycloalkyl, C3-C20 cycloalkenyl, C3-C20 heterocycloalkyl, C3-C20 heterocycloalkenyl, aryl, heteroaryl, CN, NO2, ORb1, SRb1, C(O)Rb1, COORb1, O(C)ORb1, C(O)—N(Rb1Rb2), N(Rb1)—C(O)Rb2, NRb1Rb2, S(O)Rb1, S(O)b2Rb1, S(O)2—NRb1Rb2, NRb1—S(O)2Rb2, and C(NRb1)—NRb2Rb3;
• each of Rb1, Rb2, and Rb3, independently, being H, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C20 cycloalkyl, C3-C20 cycloalkenyl, C3-C20 heterocycloalkyl, C3-C20 heterocycloalkenyl, aryl, or heteroaryl;
• each of R1, R2, and R3, independently, is H, halo, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C20 cycloalkyl, C3-C20 cycloalkenyl, C3-C20 heterocycloalkyl, C3-C20 heterocycloalkenyl, aryl, heteroaryl, CN, NO2, ORc1, SRc1, C(O)Rc1, COORc1, O(C)ORc1, C(O)—N(Rc1Rc2), N(Rc1)—C(O)Rc2, NRc1Rc2, S(O)Rc1, S(O)2Rc1, S(O)2—NRc1Rc2, NRc1—S(O)2Rc2, or C(NRc1)—NRc2Rc3;
• or R1 and R2, together with the carbon atom to which they are attached, are C3-C20 cycloalkyl, C3-C20 cycloalkenyl, C3-C20 heterocycloalkyl, or C3-C20 heterocycloalkenyl;
• each of Rc1, Rc2 and Rc3, independently, being H, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C20 cycloalkyl, C3-C20 cycloalkenyl, C3-C20 heterocycloalkyl, C3-C20 heterocycloalkenyl, aryl, or heteroaryl;
• each of L1 and L2, independently, is O, N(Rd1), C1-C10 alkylene, C1-C10 alkylcycloalkylene, C2-C10 alkenylene, C2-C10 alkynylene, or deleted;
• Rd1 being H or C1-C10 alkyl;
• and
• L3 is CH2, C(O), C(O)O, OC(O), SO, or SO2.