Host cell lines for production of antibody constant region with enhanced effector function
OwnerHaimanti Dorai, Yun Seung Kyung +1inventors
InventorsHaimanti Dorai, Yun Seung Kyung, Bernard Scallon
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Abstract
Host cell lines for biopharmaceutical production of antibodies, antibody fragments or antibody-derived fusion proteins are selected as having the capability of inducing improved cellular effector functions, e.g., Fc-medicated effector functions. The host cells are derived from the rat myeloma cell line YB2/0 and are adapted to growth in chemically-defined medium.
Claims22
An isolated cell line derived from a rat myeloma cell line YB2/0 (ATCC 1662) useful for the production of an antibody, said cell line producing glycosylated polypeptides characterized as having substantially reduced content of fucose as compared to polypeptides produced using YB2/0 (ATCC 1662).
Any invention disclosed herein.
Dependencies are inferred from the claim text.