Optimized Fc Variants and Methods for Their Generation
AssigneeXencor, Inc.
InventorsGregory Alan Lazar, Arthur J. Chirino, Wei Dang, John R. Desjarlais, Stephen Kohl Doberstein, Robert J. Hayes, Sher Bahadur Karki, Omid Vafa
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Abstract
The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
Claims19
An antibody or immunoadhesin of a parent Fc polypeptide, said antibody or immunoadhesin comprising an amino acid substitution at a position selected from the group consisting of 245, 262, and 271, and wherein numbering is according to the EU index.
An antibody or immunoadhesin of a parent Fc polypeptide, said antibody or immunoadhesin comprising an amino acid substitution selected from the group consisting of 245A, 262A, 262E, 262F, 262I, 262T, 271A, 271D, 271E, 271F, 271G, 271H, 271I, 271K, 271L, 271M, 271N, 271Q, 271R, 271S, 271T, 271V, 271W, 271Y, P244H/P245A/P247V, F241E/F243Q/V262T/V264E, F241E/F243Q/V262T/V264E/I332E, F241E/F243R/V262E/V264R, F241E/F243R/V262E/V264R/I332E, F241E/F243Y/V262T/V264R, F241E/F243Y/V262T/V264R/I332E, F241L/F243L/V262I/V264I, F241L/V262I, F241R/F243Q/V262T/V264R, F241R/F243Q/V262T/V264R/I332E, F241W/F243W/V262A/V264A, F241Y/F243Y/V262T/V264T, F241Y/F243Y/V262T/V264T/N297D/I332E, F243L/V262I/V264W, and S239D/N297D/I332E/A330Y/F241S/F243H/V262T/V264T, wherein numbering is according to the EU index.
An antibody or immunoadhesin of a parent Fc polypeptide, said antibody or immunoadhesin comprising an amino acid substitution at position selected from the group consisting of 245, 262, and 271, wherein said antibody or immunoadhesin further comprises an amino acid substitution at a position selected from the group consisting of 221, 222, 224, 227, 228, 230, 231, 223, 233, 234, 235, 236, 237, 238, 239, 240, 241, 243, 244, 245, 246, 247, 249, 250, 258, 262, 263, 264, 265, 266, 267, 268, 269, 270, 271, 272, 273, 274, 275, 276, 278, 280, 281, 283, 285, 286, 288, 290, 291, 293, 294, 295, 296, 297, 298, 299, 300, 302, 313, 317, 318, 320, 322, 323, 324, 325, 326, 327, 328, 329, 330, 331, 332, 333, 334, 335 336 and 428, wherein numbering is according to the EU index.
A method of treating a mammal in need of said treatment, comprising administering an antibody or immunoadhesin of a parent Fc polypeptide, said antibody or immunoadhesin comprising an amino acid substitution at a position selected from the group consisting of 245, 262, and 271, and wherein numbering is according to the EU index.
Dependencies are inferred from the claim text.