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US 2009/0214524 A1Published application
Methods and compositions for regulating cell cycle checkpoints
AssigneeLudwig Institute for Cancer Research
InventorsGeert J. P. L. Kops, Don W. Cleveland
Life of this patent
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Abstract
The invention relates to regulation of cell cycle checkpoints, and the application of such regulation in the treatment of disease, particularly cancer.
Claims19
A method for inducing apoptosis in a cell comprising
- reducing expression or activity of one or more mitotic checkpoint molecules.
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(canceled)
A method for treating cancer or a hyperproliferative cell disease comprising:
- administering to a subject in need of such treatment an effective amount of an agent that reduces expression or activity of one or more mitotic checkpoint molecules.
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A composition comprising a therapeutically effective amount of a siRNA specific for a mitotic checkpoint molecule,
- preferably wherein the mitotic checkpoint molecule is BubR1, Mad2, Bub3 or CENP-E.
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Dependencies are inferred from the claim text.