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US 2009/0214522 A1Published application
Process for concentration of antibodies and therapeutic products thereof
AssigneesGenentech, Inc., Novartis AG
InventorCharles M. WINTER
Life of this patent
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Abstract
The present disclosure provides a process for concentrating proteins including an ultrafiltering, a diafiltering, and a second ultrafiltering sequence, at elevated temperatures, such as above about 30° C. The disclosure also includes a process for preparing highly concentrated antibody compositions, and highly concentrated antibody products.
Claims37
A process for preparing highly concentrated antibody compositions comprising:
- a first ultrafiltering of a first antibody preparation to provide a second antibody preparation;
- a diafiltering the second antibody preparation to provide a diafiltered intermediate antibody preparation;
- and
- a second ultrafiltering of the diafiltered intermediate antibody preparation to provide a third antibody preparation;
- wherein one or more of the first ultrafiltering, second ultrafiltering, and the diafiltering are accomplished at about 30° C. to about 50° C.
2 more elements
A process for concentrating proteins comprising:
- a first ultrafiltering of a first protein mixture to provide a second protein mixture;
- a diafiltering of the second protein mixture to provide a diafiltered protein mixture;
- and
- a second ultrafiltering of the diafiltered protein mixture to provide a third protein mixture, wherein one or more of the first ultrafiltering, the diafiltering, and the second ultrafiltering are accomplished at from about 30° C. to about 50° C.
1 more element
Dependencies are inferred from the claim text.