Inhibitors of Reglll Proteins as Asthma Therapeutics
OwnerMaximillian T. Follettie, Debra D. Donaldsoninventors
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Abstract
Methods of screening for agents for treating asthma are provided. The methods involve screening for agents that decrease the production or activity of a RegIII protein that has been discovered herein to play a role in producing the symptoms and pathological complications involved in asthma. Methods of treating asthma, as well as screening for and treating with inhibitors of a RegIII protein are also provided.
Claims31
A method of screening for agents for treating asthma in a mammal, comprising:
- (a) contacting a RegIII protein with a test agent;
- and
- (b) determining if the test agent inhibits the activity of the RegIII protein, wherein a test agent that inactivates the activity of the RegIII protein is useful for treating asthma.
A method of screening for agents for treating asthma in a mammal, comprising:
- (a) contacting a nucleotide sequence encoding a reporter gene product operably linked to a mammalian RegIII protein promoter with a test agent;
- and
- (b) determining if the test agent inhibits production of the reporter gene product, wherein a test agent that inactivates the activity of the RegIII protein is useful for treating asthma.
A method for treating asthma, comprising administering to a mammal in need thereof a therapeutic amount of an agent that decreases the activity of a mammalian RegIIIγ protein.
A method for treating asthma, comprising administering to a mammal in need thereof a therapeutic amount of an agent that decreases the production of a mammalian RegIII protein.
Dependencies are inferred from the claim text.