Vascular endothelial growth factor-d (vegf)-d and functionally fragments thereof for bone repairing

A method for therapy and/or prevention of a bone disease or defect in a subject, the method comprising

• administering to the subject an effective amount of VEGF-D protein, a protein sharing at least 85% amino acid identity with the VEGF-D protein, or a functional fragment thereof.

A method for the therapy and/or prevention of a bone disease or defect in a subject, the method comprising

• administering to the subject an effective amount of a VEGF-D inducer.

A method for treatment and/or prevention of a bone and/or cartilage disease or defect comprising the step of administering an effective amount of VEGF-D, a protein sharing at Least 80% amino acid identity with the VEGF-D protein, a functional fragment thereof, or a VEGF-D inducer.

A vector for gene therapy for the treatment and/or prevention of bone diseases or defects comprising a sequence encoding VEGF-D, a protein sharing at least 80% amino acid identity with the VEGF-D protein, a functionally active fragment thereof, or a VEGF-D inducer, under the control of appropriate promoter sequences.

A method for the therapy and/or prevention of a bone disease or defect in a subject, the method comprising

• administering to the subject an effective amount of mRNA coding for the VEGF-D protein, a protein sharing at least 80% amino acid identity with VEGF-D protein or a functional fragment thereof having bone and/or cartilage regenerating function, the effective amount in a medicament to be directly injected to the site of bone repair.