Transgenic Mammals Expressing Human Preproinsulin
AssigneeXimerex, Inc.
InventorsWilliam Beschorner, Patrick E. Kudlacek
Life of this patent
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Abstract
Transgenic mammals which express human preproinsulin, methods and reagents for producing the transgenic mammals, and therapeutic methods of providing patients with insulin and C-peptide using tissues and cells from the transgenic mammals.
Claims27
A genetic construct comprising a coding sequence for human preproinsulin under control of a pig preproinsulin promoter.
(canceled)
A transgenic mammal comprising a genetic construct comprising a coding sequence for human preproinsulin under control of a pig preproinsulin promoter.
A tissue preparation obtained from a transgenic mammal comprising a genetic construct comprising a coding sequence for human preproinsulin under control of a pig preproinsulin promoter.
A preparation of cells obtained from a transgenic mammal comprising a genetic construct comprising a coding sequence for human preproinsulin under control of a pig preproinsulin promoter.
A method of providing insulin or C-peptide to a patient, comprising transferring to a patient in need thereof a preparation selected from the group consisting of:
- (a) pancreatic tissue obtained from a transgenic mammal comprising a genetic construct comprising a coding sequence for human preproinsulin under control of a pig preproinsulin promoter;
- (b) islet cells obtained from the transgenic mammal;
- (c) beta cells obtained from the transgenic mammal;
- (d) stem cells obtained from the transgenic mammal;
- (e) embryonic stem cells obtained from the transgenic mammal;
- and
- (f) adult stem cells obtained from the transgenic mammal, whereby the patient's dependence on an exogenous source of insulin is decreased.
Dependencies are inferred from the claim text.