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US 2009/0214467 A1Published application
Methods of protecting against apoptosis using lipopeptides
AssigneesThe Cleveland Clinic Foundation, Cleveland BioLabs, Inc.
InventorsAlexander N. Shakhov, Andrei Gudkov
Life of this patent
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Abstract
The use of lipopeptides as inducers of NF-κB for the protection of mammals from the effects of apoptosis is described.
Claims10
1-21. (canceled)
A compound of the formula:
- wherein,
- R1 represents H or —CO—R4,
- R2, R3 and R4 independently are H or optionally substituted C8-C16 aliphatic;
- Z is S or CH2, and
- X is a peptide characterized by one of the following:
- (a) a length of 4-40 amino acids and the first four amino acids of the peptide are according to the following table:
- Amino
- Amino
- Amino
- Amino
- Amino
- Acid 1
- Acid 2
- Acid 3
- Acid 4
- Acid 5
- D
- D
- A
- D
- D
- E
- E
- D
- E
- E
- F
- G
- E
- H
- H
- G
- K
- G
- N
- K
- K
- P
- H
- R
- M
- Q
- Q
- M
- S
- N
- R
- R
- R
- T
- R
- S
- S
- S
- S
- T
- T
- and
- b) an amino acid sequence comprising SEQ ID NOS:
- 1-52.
57 more elements
Dependencies are inferred from the claim text.