Compounds for flaviviridae treatment
OwnerBeat Weidmanninventor
Life of this patent
Estimating the term…
Abstract
Disclosed are non-immunosuppressive cyclophilin-binding cyclosporins, e.g. of formula I, Ia or II as defined herein, having useful properties in the prevention or treatment of Flaviviridae infections and Flaviviridae induced disorders.
Claims13
Use of a cyclosporin in the preparation of a pharmaceutical composition for preventing or treating Flaviviridae infections or Flaviviridae induced disorders wherein the cyclosporin (i) binds to human recombinant cyclophilin with a binding ratio (BR) of less than 0.7, BR being the log to the base 10 of the ratio of the IC50 of the cyclosporin to the IC50 in a simultaneous test of cyclosporin A as measured in a competitive ELISA test;
- and (ii) has an activity in the Mixed lymphocyte Reaction of not more than 5% that of cyclosporin A.
Dependencies are inferred from the claim text.