Back to results
US 2009/0214452 A1Published application
Arginine Heteromers for Topical Administration
AssigneeRevance Therapeutics, Inc.
InventorJacob M. Waugh
Life of this patent
Estimating the term…
Abstract
The invention is directed to a strategy for providing therapeutic or cosmetic benefit to skin by topically applying arginine chemically bound to a second (non-oligo arginine) compound in order to increase transepithelial delivery of arginine through a combination of increased solubility and flux across the skin. The arginine heteromers of the invention can add other complementary or beneficial properties for the skin beyond those that are arginine-related.
Claims43
A heteromer of formula I:
- A-R I
- wherein A is arginine covalently bound to a second compound R such that the guanadino group of the arginine remains unreacted and wherein R is an organic molecule wherein the heteromer has greater flux across the skin than arginine alone.
A composition comprising a heteromer of formula I
- A-R I
- wherein A is arginine covalently bound to a second compound R such that the guanadino group of the arginine remains unreacted and wherein R is an organic molecule wherein the heteromer has greater flux across the skin than arginine alone.
A method for providing a beneficial effect to skin comprising:
- topically applying a composition comprising a heteromer of formula I:
- A-R I
- wherein A is arginine covalently bound to a second compound R such that the guanadino group of the arginine remains unreacted and wherein R is an organic molecule wherein the heteromer has greater flux across the skin than arginine alone.
Dependencies are inferred from the claim text.