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US 2009/0214443 A1Published application
Method for retarding systemic delivery rate for easily absorbable active agents
OwnerThomas Chaninventor
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Abstract
Drugs such as hormones, which are easily absorbable through the stratum corneum into the vascular network, are administered to the skin of a patient in an absorption retarding matrix material, thereby retarding the rate at which the drug penetrates into and through the skin.
Claims8
A method for retarding the rate of delivery of an easily-absorbable hormone, comprising,
- topically administering to said patient a composition comprising an absorption-retarding matrix material and an amount of said hormone;
- wherein the matrix formed from the matrix-forming material retards the rate at which the hormone penetrates into and through the skin.
A method for retarding the rate of delivery of a normally readily systemically absorbed hormone to a patient in need thereof, comprising,
- topically administering to said patient a composition comprising a skin-substantive polymerizable matrix material and an amount of said hormone;
- wherein the matrix formed from the skin-substantive material does not penetrate into or through the skin and substantially preferentially partitions the hormone in the body thereof and retards the rate at which the hormone penetrates into and through the skin such that the amount of said hormone which enters into the patient's vascular network is sufficient to achieve its desired physiological or biological function but less than an amount which causes or promotes adverse side effects.
Dependencies are inferred from the claim text.